Su JH, Deng G, Cotman CW.
Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain.
Brain Res. 1997 Nov 7;774(1-2):193-9.
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TUNEL staining is beginning to be popular in AD research. This is the first document to explain the relationship between DNA damage and tangle formation.
These data are consistent with other data (e.g. from Brad Hyman lab) suggesting that neuron death exceeds the number of NFT.