. Neurofilament protein levels in CSF are increased in dementia. Neurology. 1999 Mar 23;52(5):1090-3. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
NFL
(CSF)
AD
(37)
348 ± 216
pg/mL
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
NFL
(CSF)
CTRL-
CNC
(39)
156 ± 80
pg/mL
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
VaD
(20)
674 ± 578
pg/mL
ELISA;
Other/Not Specified;
In-house
Román et al., 1993
albumin ratio
(CSF/Blood)
AD
(37)
6.3 ± 2.3
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
In-house
McKhann et al., 1984
albumin ratio
(CSF/Blood)
CTRL-
CNC
(39)
5.7 ± 2.1
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
In-house
albumin ratio
(CSF/Blood)
VaD
(20)
7.6 ± 3
(CSF mg/L)/(Serum g/L)
Nephelometry;
Other/Not Specified;
In-house
Román et al., 1993

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Comments

  1. But these levels apparently do not differentiate vascular dementia, FTD and AD.

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