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Kokkoni N, Stott K, Amijee H, Mason JM, Doig AJ. N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure. Biochemistry. 2006 Aug 15;45(32):9906-18. PubMed. Recommends Please login to recommend the paper. Comments Boris Schmidt Darmstadt Technical University Posted: 17 Aug 2006 There have been many reports of peptide sequences as anti-amyloidgenic agents; so far all of them failed in vivo. Therefore crucial questions are: do these peptides make it into the brain? are the orally available? is fibril disruption still a target? are 100 uM or 10 uM concentrations of Ab40/42 sufficient for compound profiling? Are the compounds selective, do they target other protein aggregates? View all comments by Boris Schmidt Make a Comment To make a comment you must login or register.
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Darmstadt Technical University
There have been many reports of peptide sequences as anti-amyloidgenic agents; so far all of them failed in vivo.
Therefore crucial questions are:
do these peptides make it into the brain?
are the orally available?
is fibril disruption still a target?
are 100 uM or 10 uM concentrations of Ab40/42 sufficient for compound profiling?
Are the compounds selective, do they target other protein aggregates?
Make a Comment
To make a comment you must login or register.