. Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science. 2003 May 2;300(5620):808-12. PubMed.


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  1. This work further confirms the importance of axonal retrograde transport in the development of neurodegeneration (at least in motor neuron degeneration). Although whether the concept applies to Alzheimer research remains to be examined, it seems worth trying.