. Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. FASEB J. 2001 Dec;15(14):2680-8. PubMed.

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  1. Another mechanism of UBB+1 activity in AD? -- Eddie Koo

  2. Abnormal translation of transcripts has been reported for APP, and also for ubiquitin. This significance of these +1 proteins is unknown, but this interesting article shows that they can be toxic. When judging this work though, it is important to remember that the amount of +1 protein in the brain is much less than would be induced by a transfection. Thus, although the ubiquitin-B +1 protein has now been shown to be toxic, the effects of low level ubiquitin-B +1 on the brain remain to be determined. -- Benjamin Wolozin