Kneipp J, Beekes M, Lasch P, Naumann D.
Molecular changes of preclinical scrapie can be detected by infrared spectroscopy.
J Neurosci. 2002 Apr 15;22(8):2989-97.
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Q & A with Gabrielle Strobel, ARF, and Dieter Nauman, Robert Koch Institute, Berlin.
Q: Could this technique be developed to detect early pathological changes in Alzheimer Disease? Can it pick up low-molecular weight protein aggregates?
A: Our diagnostic FT-IR technique can definitely be used also for the analysis of pathological changes in Alzheimer's diseased tissue. A similar FT-IR approach that aimed, however, at the in-situ deposition of Aβ in tissues has been published recently (Choo et al. 1996) FT-IR is already being used to characterize low molecular-weight aggregates.
Q: Could FT-IR be adapted to be used in live animals?
A: The FT-IR technique described is on tissues, there is no way to use it for live animals or humans, as e.g. MRI. But we are currently developing a similar TSE diagnostic technology that can be used on blood serum of individuals. ‑ Gabrielle Strobel
Choo LP, Wetzel DL, Halliday WC, Jackson M, LeVine SM, Mantsch HH.
In situ characterization of beta-amyloid in Alzheimer's diseased tissue by synchrotron Fourier transform infrared microspectroscopy.
Biophys J. 1996 Oct;71(4):1672-9.