Schon EA, Area-Gomez E.
Mitochondria-associated ER membranes in Alzheimer disease.
Mol Cell Neurosci. 2012 Aug 24;
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This paper puts in perspective the very interesting results from Eric Schon's laboratory regarding the apparent central role of the mitochondrial-associated membranes (MAM) in Alzheimer's disease. These discoveries revise our understanding of the presenilins and γ-secretase activity in Alzheimer's disease. The paper should also be read in association with the recent publication by Hamasaki et al. in Nature showing that autophagosomes form at the MAM—thus supporting the proposed connection between the presenilins and autophagy.
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T.
Autophagosomes form at ER-mitochondria contact sites.
Nature. 2013 Mar 21;495(7441):389-93.