Block ML, Zecca L, Hong JS.
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms.
Nat Rev Neurosci. 2007 Jan;8(1):57-69.
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Microglia and inflammation are the common denominator among the diverse list of neurodegenerative diseases. Microglial activation has been implicated as a critical mechanism responsible for the progressive nature of neurodegeneration. There are limited studies on the activation of microglia in response to environmental toxins, endogenous proteins, and neuronal death results in the production of toxic factors that propagate neuronal injury.
This review provides a comprehensive overview of microglia-related neurotoxicity. It opens up new avenues in understanding how microglia damage the neurons, also how the microglia respond to neuronal damage in a self propelling cycle of neuron death. It also enriches our understanding in imaging of the overactivated microglia, a good target for therapeutic intervention.