. Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice. Hum Mol Genet. 2013 Jun 19; PubMed.

Recommends

Please login to recommend the paper.

Comments

Make a Comment

To make a comment you must login or register.

Comments on this content

  1. The authors of this interesting report have nicely demonstrated a new method of inhibiting micro RNAs (miRNAs) in vivo in a mouse model of ALS. Essentially, they have utilized oligonucleotides as miRNA inhibitors. By targeting one such miRNA, miRNA-155, they demonstrate improvement in their ALS mouse model, about a 10-day prolonged survival. From a neuroinflammation perspective, what I find most intriguing is that miRNA-155 is avidly taken up by microglia and astrocytes. While the authors do not further investigate a putative mechanism to account for this, it would be interesting to determine if an active process is at work here (e.g., fluid-phase pinocytosis) or whether some form of glial-neuronal interaction is taking place. Nonetheless, this work raises our awareness of the therapeutic potential of blocking miRNAs for neurodegenerative disease.

This paper appears in the following:

News

  1. Blocking a MicroRNA Slows Motor Neuron Disease in Mice