. MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice. J Neurosci. 2013 Apr 17;33(16):7027-37. PubMed.

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  1. The article by Browne et al. under "Related Papers" (Browne et al., 2013) directly addresses why it may be beneficial not only reduce to amyloid-β with targeted antibodies, but also to promote an anti-inflammatory Th2 and T regulatory response towards Th1 cell-mediated inflammation. This could be important, because once activated by amyloid-β, it is likely that Th1 cell-mediated inflammation will continue and may require only residual amounts of amyloid to maintain the inflammatory response and promote progression of disease pathology. Passive vaccination with amyloid-β-reducing monoclonals won't address the cell-mediated inflammation, and a Th1-type response to an active vaccine could exacerbate the problem.

    References:

    . IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. J Immunol. 2013 Mar 1;190(5):2241-51. PubMed.

    View all comments by Cynthia Lemere

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