. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2356-61. PubMed.


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  1. Stalling the Ravages of Aging (and Alzheimer's?) With Antioxidants

    "Since its conception nearly 50 years ago (Harman, 1956), the free radical theory of aging has found some of its best support from studies of brain aging and Alzheimer disease (Smith et al., 1991; Smith et al., 1996). The significance of altered redox homeostasis in both aging and AD is best appreciated by studies showing protection by antioxidants in aging (Joseph et al., 1998, 1999) and AD (Sano et al., 1997; Smith et al., 1999). The present paper by Liu et al., found that antioxidants targeting mitochondria, such as lipoic acid and carnitine, reverse both age-related oxidative damage and behavioral deficits. Since redox changes in AD are similar in nature, albeit greater, to those in aging, these studies indicate that effective therapeutics can be found for AD, and, more importantly, that such treatment may be efficacious for behavioral deficits." -George Perry and Mark A. Smith, Case Western Reserve University, Cleveland, Ohio.


    Harman D (1956) Ageing: a theory based on free radical and radiation chemistry. J Gerontol 11, 298-300.

    Smith MA, Petot GJ, Perry G (1999) Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease. J Alzheimer's Disease 1:203-206.