Maye J, Gidicsin C, Pepin L, Becker JA, Blacker D, Rentz D, Locascio J, Marshall G, Amariglio R, Lorius N.
Maternal Dementia Age of Onset in Relation to Amyloid Burden in Non-Demented Offspring.
Human Amyloid Imaging Abstract. 2012 Jan 1;
Family history of dementia (FH) is a significant risk factor for sporadic, late-onset Alzheimer’s disease (AD), particularly when the FH is maternal and when the age of dementia onset (AO) is younger. Non-demented individuals have greater amyloid burden regardless of age, gender, and APOE carrier status when there is a maternal FH of dementia (mFH) compared to either those with a paternal FH (pFH) or those without a FH. We hypothesized that younger parental AO of dementia would relate to greater beta-amyloid burden and that the effect would be greater in those with a maternal history of dementia.
Detailed family history and PIB PET was acquired in43 non-demented individuals participating in the Harvard Aging Brain Study with mean ±SD age4 ±8. Forty-one subjects were excluded, e.g., because one parent died before age3. Of the remaining02 individuals (CDR0, N=73; CDR0.5, N=29) reported a single-parent history of dementia mFH+ and4 pFH+. PiB retention (DVR, cerebellar reference) was measured in a global cortical region and its relation to AO was evaluated with general linear models.
Parental dementia AO (range4 –0 y) did not differ between mothers (78 ±8y) and fathers (73 ±9y; p>0.1). Higher prevalence of dementia in mothers was not accounted for by parental longevity (Kaplan-Meier analysis). Similar to previous reports, PiB retention in this sample was greater in mFH+ subjects compared to subjects with no FH (p0.9).
Our results suggest that greater amyloid burden in offspring is associated with younger age at dementia onset when the affected parent was female, not when the affected parent was male, and that the effect is independent of APOE status.