. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.

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  1. This, and the remarkable paper from from Francis and colleagues, mark real progress in the dissection of the gamma secretase complex... perhaps we are now close to knowing all it's components

    References:

    . aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell. 2002 Jul;3(1):85-97. PubMed.

  2. First of a series of papers on APH-1 and gamma cleavage in mammalian cells, following the paper from Exelixis on c.elegans and flies.