. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.


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  1. This, and the remarkable paper from from Francis and colleagues (Dev Cell. 2002 Jul;3(1):85-97) mark real progress in the dissection of the gamma secretase complex... perhaps we are now close to knowing all it's components

  2. First of a series of papers on APH-1 and gamma cleavage in mammalian cells, following the paper from Exelixis on c.elegans and flies.