. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 5;43(3):333-44. PubMed.

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  1. Beautiful and elaborate work. It would be of interest to examine in detail whether LRP-dependent clearance affects parenchymal amyloidosis or amyloid angiopathy, and whether LRP-dependent clearance is more associated with clearance through the blood-brain barrier or through astrocytotic endocytosis/phagocytosis.

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