Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S.
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model.
Mol Psychiatry. 2012 Jul 31;
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With the twin papers (one on AD and the other on α-synucleinopathy) in Mol. Psychiatry, Sam Gandy's lab revive the importance of Dimebon in amyloid disorders. Both these papers suggest a role of Dimebon in inducing autophagy and thereby ameliorating disease pathology. Elegant work that has implications for therapy.