The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease.
J Cell Mol Med. 2005 Jul-Sep;9(3):531-41.
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Nagy proposes the very intriguing hypothesis that it is not cell cycle activation per se that may cause neurodegeneration in AD, but rather, it is the inability of AD neurons to return to the differentiated state after normal activation of cell cycle proteins,perhaps to effect synaptic remodeling. One may not agree with all the details of the hypothesis, but the concept is appealing and is consistent with published data.
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