Kauppi K, Nilsson LG, Adolfsson R, Eriksson E, Nyberg L.
KIBRA polymorphism is related to enhanced memory and elevated hippocampal processing.
J Neurosci. 2011 Oct 5;31(40):14218-22.
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Interesting papers. It's quite amazing that a protein linked to enhanced memory performance can be linked to synaptic plasticity, and AMPAR trafficking. The study by Makuch et al. provides more evidence that AMPA-R trafficking is an important regulated process in memory formation. Given that the T allele may provide some protection against AD, it supports a role for defects in AMPAR trafficking in AD. In this context it would be nice to know how the T allele changes AMPAR trafficking in model systems.
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