. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem. 2002 Feb 1;277(5):3767-75. PubMed.

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  1. Three studies on the app-jip interaction. What does this do?

  2. Despite the dominance of the amyloid hypothesis of Alzheimer's disease, understanding the function of APP and its role in apoptosis remains an important avenue of research. This article describes an important new line of evidence that could explain previous observations linking mutations in APP with increases in apoptosis.