Investigative models for determining hormone therapy-induced outcomes in brain: evidence in support of a healthy cell bias of estrogen action.
Ann N Y Acad Sci. 2005 Jun;1052:57-74.
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This interesting hypothesis may well explain the apparent discord between human observational and trial results with hormone therapy. There may be other biological explanations, but any of these are more interesting and potentially valuable than to write off observational results as due exclusively to "bias and confounding."