. Intra- and interspecific variation in primate gene expression patterns. Science. 2002 Apr 12;296(5566):340-3. PubMed.

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  1. Its very nice to see the beginnings of a test for the King & Wilson 1975 idea, (especially for both RNA and protein). There's still a long way to go to dissect out the quantitative effects on the alternative splice forms for the various mRNAs in the plethora of cell-types within the brain. The subset of differences relevant to neurodegenerative disease differences among apes will probably be harder to disentangle than a similar approach entirely within human families/populations, where the number of differences can be more focused and relevant (but time will tell)."

    View all comments by George Church