Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.
Neurochem Int. 2008 May;52(6):920-34.
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Supplementary information for this paper is available at the PolygenicPathways site. This includes details of the interactions of HSV-1 with host transcription factors and a listing of their downstream targets in relation to genes implicated in Alzheimer disease. An annotated HSV-1 genome is also provided, with details of some of the interactions of the herpes simplex genes and proteins with those of the host.
This site has also been updated. Each table of susceptibility genes (see also Alzgene) now includes links to GeneCards, provided by the Weizmann Institute of Science. A number of Kegg pathways provided by the Kanehisa Laboratories are also illustrated. Genes implicated in AD are highlighted in these maps.