. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73. PubMed.

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  1. This very interesting paper provides another link in our understanding of the role of APP in synaptogenesis and Alzheimer's disease. Understanding the function of APP and its molecular partners (e.g., reelin) will undoubtedly provide key insights into the mechanisms of synaptic loss and disease progression, the role of ApoE, and the potential roles of reelin and the LDL receptor family in pathogenesis.

    Just to set the record straight, while the paper by Qiu et al. in J Neuroscience is undoubtedly important, there were several seminal papers from our group prior to the Qiu paper, which provided both in vitro and in vivo evidence that APP was involved in neurite outgrowth (Milward et al., 1992; Small et al., 1994; Williamson et al., 1995; Clarris et al., 1995).

    References:

    . The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron. 1992 Jul;9(1):129-37. PubMed.

    . A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci. 1994 Apr;14(4):2117-27. PubMed.

    . Affinity purification of proteoglycans that bind to the amyloid protein precursor of Alzheimer's disease. J Neurochem. 1995 Nov;65(5):2201-8. PubMed.

    . Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system. Brain Res Dev Brain Res. 1995 Aug 28;88(1):87-95. PubMed.

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  1. Another Take on APP and Neurite Outgrowth—The Role of Reelin