. Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy. J Biol Chem. 2004 Dec 31;279(53):56004-13. PubMed.


Please login to recommend the paper.


  1. We already know that another candidate enzyme for the in vivo degradation of Aβ plasmin is inhibited by aluminium (Al) (Korchazhkina et al., 2002). Perhaps Al might also inhibit IDE?


    . The degradation of Abeta(25-35) by the serine protease plasmin is inhibited by aluminium. J Alzheimers Dis. 2002 Oct;4(5):357-67. PubMed.

    View all comments by Chris Exley

Make a Comment

To make a comment you must login or register.

This paper appears in the following:


  1. IDE—Levels Up, But Activity Down, in Amyloid-Burdened Vasculature