. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. Am J Pathol. 2007 Dec;171(6):2012-20. PubMed.


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  1. Based upon neuropathological and biochemical observations of the human brain, a relevant model of Alzheimer pathology should present a synergy between tauopathy and amyloidosis. The model presented here sounds good.


    . Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology. 2002 Aug 13;59(3):398-407. PubMed.

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