. Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype. Neurobiol Aging. 2017 Mar;51:104-112. Epub 2016 Dec 5 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβ40
(CSF)
AD
(75)
3899 ± 1376
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
McKhann et al., 1984; 1986
Aβ40
(CSF)
CTRL-
CNC
(65)
5241 ± 1487
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Aβ40
(CSF)
FTD
(41)
4530 ± 1536
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Neary et al., 1998
Aβ40
(CSF)
MCI-AD
(35)
4219 ± 1327
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Petersen, 2004; McKhann et al., 1984
Aβ40
(CSF)
MCI-Stable
(61)
3786 ± 1360
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Petersen, 2004
Aβ42
(CSF)
AD
(75)
259.7 ± 105
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
McKhann et al., 1984; 1986
Aβ42
(CSF)
CTRL-
CNC
(65)
675.2 ± 289.8
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Aβ42
(CSF)
FTD
(41)
682.9 ± 290.5
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Neary et al., 1998
Aβ42
(CSF)
MCI-AD
(35)
314.5 ± 78.9
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Petersen, 2004; McKhann et al., 1984
Aβ42
(CSF)
MCI-Stable
(61)
478.9 ± 195
pg/mL
ELISA;
Euroimmun;
Euroimmun AG
Petersen, 2004
albumin ratio
(CSF/Blood)
AD
(75)
7.6 ± 3.4
ratio
Turbidimetry;
Roche Cobas Analyzer;
Roche
McKhann et al., 1984; 1986
albumin ratio
(CSF/Blood)
CTRL-
CNC
(65)
6.3 ± 2.9
ratio
Turbidimetry;
Roche Cobas Analyzer;
Roche
albumin ratio
(CSF/Blood)
FTD
(41)
8.6 ± 5.5
ratio
Turbidimetry;
Roche Cobas Analyzer;
Roche
Neary et al., 1998
albumin ratio
(CSF/Blood)
MCI-AD
(35)
7.1 ± 3.3
ratio
Turbidimetry;
Roche Cobas Analyzer;
Roche
Petersen, 2004; McKhann et al., 1984
albumin ratio
(CSF/Blood)
MCI-Stable
(61)
6.3 ± 2.5
ratio
Turbidimetry;
Roche Cobas Analyzer;
Roche
Petersen, 2004
albumin ratio
(CSF/Blood)
VaD
(28)
8.7 ± 3.7
ratio
Turbidimetry;
Roche Cobas Analyzer;
Roche
Román et al., 1993; 1986

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