de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, Mackenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM, Holton J, Lees A, Revesz T, Mann DM. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol. 2006 Apr;111(4):329-40. PubMed.

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  1. This paper corroborates that tauopathies can be described as a code-bar (triplet in AD, upper doublet in PSB and CBD, lower doublet in PiD, lower singulet in DM, and more to come...) that reflects the aggregation of specific sets of tau isoforms, and likely the involvement of specific neuronal populations.

    View all comments by Andre Delacourte

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