. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010;5(9):e12244. PubMed.

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  1. This work in humans is nicely supported by studies performed in mice by a Japanese team earlier this year (incidentally, published in the same journal). The mouse work showed that vitamin B deficiency caused cognitive impairment, which could be blocked with an antibody against homocysteic acid, another cysteine metabolite (Hasegawa et al., 2010).

    References:

    . Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS One. 2010 Jan 20;5(1):e8593. PubMed.