Larvie M, Van Leemput K, Becker JA, Maye JE, Carmasin JS, Sperling RA, Fischl B, Johnson KA.
Hippocampal substructural volume in relation to amyloid deposition.
Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;
Background: A link has been postulated between brain amyloid deposition in the preclinical stages of Alzheimer’s
disease (AD) and early downstream processes of neurodegeneration. With recent advances in brain volumetry
using high field MRI, we can quantify substructural volumes within the hippocampus, a major target of degeneration
Objective: We tested the hypothesis that amyloid deposition was related to an AD-like pattern of hippocampal
degeneration involving the subiculum and CA1 subfields.
Methods: PiB PET and MRI were acquired in 117 subjects: 74 unimpaired control subjects (CS; CDR=0;
mean ± SD age 70±6), 28 subjects with mild cognitive impairment (MCI; CDR=0.5; age 74±8), and
15 patients with AD (CDR=1; age 71±8 years). Hippocampal substructural volumes were calculated (Van Leemput
et al 2009) in presubiculum, subiculum, CA1, CA2-3, CA4-dentate, fimbria, and the hippocampal fissure and
adjusted for intracranial volume.
Results: Group volume differences (CS>MCI>AD; ANOVA) were highly significant (pConclusions: These preliminary results suggest that hippocampal substructure volumes differ according to
diagnostic group and are age-related. Although amyloid is strongly associated with reduced volumes across the
full spectrum of normal to AD, it is not clear that the association holds within groups.