. A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiol Aging. 2009 Sep;30(9):1393-405. PubMed.


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  1. Further evidence for the heterogeneity of protein aggregates, and a reminder that each transgenic model may have specific pathologic characteristics that should be considered when selecting a model for experimental purposes.

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