. High-dose estradiol improves cognition for women with AD: results of a randomized study. Neurology. 2001 Aug 28;57(4):605-12. PubMed.


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  1. The high dose of estrogen replacement would be a potent therapeutic and its effect is expected to be pharmaceutically separated from a risk of cancer induction.

  2. Slightly better outcome than recent randomized trial by ADCS.

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