Wu CW, Liao PC, Yu L, Wang ST, Chen ST, Wu CM, Kuo YM.
Hemoglobin promotes Abeta oligomer formation and localizes in neurons and amyloid deposits.
Neurobiol Dis. 2004 Dec;17(3):367-77.
PubMed.
This is an interesting observation, but if the mechanism involves "circulation leakage," other plasma amyloidogenic proteins such as amyloid P component, insulin, and immunoglobulin would also contribute to Aβ amyloidosis. If Hb is a specific/selective and dominant colocalizing protein among the other plasma proteins, the origin of SP-associated Hb is likely to be neuronal or glial cells.
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RIKEN Center for Brain Science
This is an interesting observation, but if the mechanism involves "circulation leakage," other plasma amyloidogenic proteins such as amyloid P component, insulin, and immunoglobulin would also contribute to Aβ amyloidosis. If Hb is a specific/selective and dominant colocalizing protein among the other plasma proteins, the origin of SP-associated Hb is likely to be neuronal or glial cells.
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