Miskiewicz K, Jose LE, Yeshaw WM, Valadas JS, Swerts J, Munck S, Feiguin F, Dermaut B, Verstreken P.
HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.
Cell Rep. 2014 Jul 10;8(1):94-102. Epub 2014 Jun 26
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This is an interesting study and links two pathways in a fly model of ALS. It is possible that the same pathways are relevant in humans, since there is an association of ELP3 alleles with ELP3 expression and ALS disease status in humans, and the changes are in a consistent direction with what has been observed in this study. The Bruchpilot equivalent in humans does not contain a long tail, so the acetylation target may be different. If similar acetylation relationships between the two pathways exist in humans, and the effects on neurotransmission and disease status also exist, then a therapeutic approach to consider would be to increase ELP3 expression.