Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE.
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
Hum Mol Genet. 2006 Sep 15;15(18):2743-51.
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Inhibitor of Htt misfolding and oligomerization reduces polyQ toxicity in vivo.
EGCG is a frequent hitter in HTS, like many catechols. It was reported to inhibit BACE and the 20 S proteasome. Care has to be taken to work under inert atmosphere in order to avoid oxidation-derived artefacts. It's abundant in food and beverages, but does that make it a good starting point for drug development?
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