There may be more than one factor contributing to the probabilistic nature of the relationship between genes and risk of late-onset AD. The author recognizes one: the complexity of the disease. An entirely different, and not mutually exclusive, factor lies in epigenetic effects. See Scarpa et al. (2006) for a review. In addition, there is recent evidence for epigenetic differences in identical twins discordant for AD.
References:
Scarpa S, Cavallaro RA, D'Anselmi F, Fuso A.
Gene silencing through methylation: an epigenetic intervention on Alzheimer disease.
J Alzheimers Dis. 2006 Aug;9(4):407-14.
PubMed.
Comments
Banner Research Institute
There may be more than one factor contributing to the probabilistic nature of the relationship between genes and risk of late-onset AD. The author recognizes one: the complexity of the disease. An entirely different, and not mutually exclusive, factor lies in epigenetic effects. See Scarpa et al. (2006) for a review. In addition, there is recent evidence for epigenetic differences in identical twins discordant for AD.
References:
Scarpa S, Cavallaro RA, D'Anselmi F, Fuso A. Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. J Alzheimers Dis. 2006 Aug;9(4):407-14. PubMed.
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