. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10;42(22):6664-73. PubMed.

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  1. The statement in the paper, "any strategy aimed at altering APP proteolysis will have to take into account possible effects on signaling by APLP1 and 2," sounds quite logical and resonable. One remaining major remainig question is what the biological functions of the seemingly constitutively generated ICDs of APP and APLPs are.