. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease. Arch Neurol. 2008 Aug;65(8):1102-7. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβx-40
(CSF)
AD
(87)
4927 ± 1217
pg/mL §
Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery
McKhann et al., 1984
Aβx-40
(CSF)
CTRL-
CNC
(33)
5307 ± 1080
pg/mL §
Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery
Aβx-40
(CSF)
MCI-AD
(45)
4464 ± 1541
pg/mL §
Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery
McKhann et al., 1984
Aβx-40
(CSF)
MCI-Stable
(52)
4949 ± 1192
pg/mL §
Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery
Petersen, 2004
sAPPα
(CSF)
AD
(87)
653 ± 252
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
McKhann et al., 1984
sAPPα
(CSF)
CTRL-
CNC
(33)
538 ± 223
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
sAPPα
(CSF)
MCI-AD
(45)
751 ± 383
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
McKhann et al., 1984
sAPPα
(CSF)
MCI-Stable
(52)
772 ± 276
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
Petersen, 2004
sAPPβ
(CSF)
AD
(87)
399 ± 140
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
McKhann et al., 1984
sAPPβ
(CSF)
CTRL-
CNC
(33)
369 ± 117
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
sAPPβ
(CSF)
MCI-AD
(45)
435 ± 201
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
McKhann et al., 1984
sAPPβ
(CSF)
MCI-Stable
(52)
487 ± 178
ng/mL §
Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
Petersen, 2004

§ Data supplied to Alzforum by author

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