Kaizer RR, Corrêa MC, Gris LR, da Rosa CS, Bohrer D, Morsch VM, Schetinger MR. Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes. Neurochem Res. 2008 Nov;33(11):2294-301. PubMed.
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Ecole Pratique des Hautes Etudes
Of course, as stated in the Kaizer et al. paper, "Aluminum (Al), a neurotoxic agent, has been associated with Alzheimer disease (AD)." Association, however, does not demonstrate causality.
Moreover, it is useful to remember that the whole story of a relationship between aluminum and AD started with a Klatzo et al. 1965 paper. These authors thought that, through Al implantation, they had reproduced the "neurofibrillary degeneration" characteristic of AD, and in consequence provided a model for this disease. They were in error: Terry and Pena, in the same issue of the same journal, showed that the filaments produced by Al in the rabbit brain are quite different from the paired helical filaments (PHF) forming the tangles of AD. Moreover, we could show (Foncin and El Hachimi, 1986) that (accidental) Al implantation in the human brain causes a neurological disease entirely distinct from AD, and reminiscent of the epileptic disease provoked in the cat by experimental brain implantation of "aluminum cream."
I think it misleading to let the reader think that a paper using an aluminum model, interesting as it is per se, might be relevant to AD.
See also:
FONCIN J.F. and El HACHIMI K.H. (1986): "Neurofibrillary degeneration" in Alzheimer's disease, with a contribution to aluminum pathology in man; in A. Bes et al, eds: Senile dementia: early detection, John Libbey Eurotext, pp. 191-201.
References:
KLATZO I, WISNIEWSKI H, STREICHER E. EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS. J Neuropathol Exp Neurol. 1965 Apr;24:187-99. PubMed.
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