van der Flier WM, Schoonenboom SN, Pijnenburg YA, Fox NC, Scheltens P.
The effect of APOE genotype on clinical phenotype in Alzheimer disease.
Neurology. 2006 Aug 8;67(3):526-7.
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This paper presents interesting but preliminary data showing an increased E4 frequency in patients with "memory phenotype" of AD compared to the "non-memory" phenotype where patients presented with, for example, agnosia or apraxia. Implicitly, this finding argues for genetic-based subtypes of AD.