Wang JC, Kwon JM, Shah P, Morris JC, Goate A.
Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.
Neurology. 2000 Dec 12;55(11):1644-9.
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The difficulty we have had proving a role for the polymorphisms in the APOE promoter in AD (and the general consensus seems to be that they have a role), illustrates the difficulty we will have in determining whether genetic variability at other non-coding sites influences disease.
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