. Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. J Neurosci. 2012 Jun 13;32(24):8341-53. PubMed.


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  1. In her previous series of papers, Dr. Stutzmann reported a number of
    abnormalities in calcium signaling and synaptic function resulting
    from presenilin FAD mutations. In the present paper, her group offers
    a comprehensive and physiologically relevant analysis of synaptic
    dysfunction in AD. Interestingly, her group shows abnormalities on
    both presynaptic and postsynaptic sides of the synapse in neurons from PS1-FAD mice, which helps to reconcile a number of previous
    observations. Overall, it is an excellent study of synaptic
    dysfunction in AD.

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