White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R. Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation. Brain Res. 2003 Mar 21;966(2):231-44. PubMed.
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Yale University School of Medicine
This is a complicated story in which peptides known to form fibrillar aggregates are found to increase the levels of APP and APLP2 in primary cultures of astrocytes and neurons. The increase in APP and APLP2 only in cultures exposed to fibrillar peptides was said to be assessed by electron microscopy. Since PrP106-126 and Abeta peptides were found to bind to recombinant APP and APLP2, it was suggested that direct binding of fibrillar material was responsible for the increase in production of APP and APLP2. How this came about was not explained. Extensive washing of the cultures blocked this effect. The authors proposed that removal of most of the fibrillar material from direct contact with the cells accounted for the reduction, but this is one of many possible explanations.
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