. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet. 2002 Oct 1;11(21):2615-24. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. Convincing evidence that ADAM10 is requred for notch S2 cleavage but unclear how it may be involved in APP alpha secretase cleavage. Ultimately, alpha-secretase may indeed be a collection of protease rather than one, could gamma be the same??

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. All About ADAM10—The Neuronal α-Secretase