Diet and Risk of Amyotrophic Lateral Sclerosis: Is Lifestyle Important?.
JAMA Neurol. 2014 Jul 14;
Please login to recommend the paper.
Make a Comment
This is the first large, prospective study of dietary fatty acid intake in ALS and a much more robust confirmation of the association seen in two prior retrospective case-control studies (Veldink et al., 2007; Okamoto et al., 2007). The authors also commented on the recent, apparently contradictory finding by Yip et al. (Yip et al., 2013) that showed that dietary eicosapentaenoic acid (EPA), a marine-derived fatty acid, did not improve survival in the SOD1 ALS mouse model. One possible explanation for this discrepancy is the different kinds of fatty acids used. The marine-derived omega-3 fatty acids (like EPA) used in the Yip paper were only marginally significant in the Fitzgerald JAMA Neurology study; Fitzgerald and colleagues found that plant-derived fatty acids like alpha-linolenic acid were more effective. However, as we have learned from the Alzheimer's experience with omega-3 supplementation, even a strong epidemiological association may not translate into an effective treatment.
Veldink JH, Kalmijn S, Groeneveld GJ, Wunderink W, Koster A, de Vries JH, van der Luyt J, Wokke JH, Van den Berg LH.
Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis.
J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):367-71. Epub 2006 Apr 28
Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Inaba Y, Nagai M.
Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan.
Ann Epidemiol. 2009 Jun;19(6):359-64.
Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC, Malaspina A, Bendotti C, Michael-Titus A.
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
PLoS One. 2013;8(4):e61626. Print 2013
To make a comment you must login or register.