Diet and Risk of Amyotrophic Lateral Sclerosis: Is Lifestyle Important?.
JAMA Neurol. 2014 Jul 14;
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This is the first large, prospective study of dietary fatty acid intake in ALS and a much more robust confirmation of the association seen in two prior retrospective case-control studies (Veldink et al., 2007; Okamoto et al., 2007). The authors also commented on the recent, apparently contradictory finding by Yip et al. (Yip et al., 2013) that showed that dietary eicosapentaenoic acid (EPA), a marine-derived fatty acid, did not improve survival in the SOD1 ALS mouse model. One possible explanation for this discrepancy is the different kinds of fatty acids used. The marine-derived omega-3 fatty acids (like EPA) used in the Yip paper were only marginally significant in the Fitzgerald JAMA Neurology study; Fitzgerald and colleagues found that plant-derived fatty acids like alpha-linolenic acid were more effective. However, as we have learned from the Alzheimer's experience with omega-3 supplementation, even a strong epidemiological association may not translate into an effective treatment.
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Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis.
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Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Inaba Y, Nagai M.
Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan.
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Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC, Malaspina A, Bendotti C, Michael-Titus A.
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis.
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