. Developmental exposure to manganese induces lasting motor and cognitive impairment in rats. Neurotoxicology. 2015 Sep;50:28-37. Epub 2015 Jul 26 PubMed.

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  1. This is an important observation in an animal model. A recent publication in the same journal by Bowler and colleagues (July 2015) suggests that environmental exposure to manganese influences performance on tests of working and visuospatial memory function in people with a mean age of 56 years. How environmental and occupational neurotoxicant exposure may interact with the progression of age-related mild cognitive impairment needs to be better elucidated through additional epidemiological studies and with preclinical models of aMCI. This work will provide important data that will prove useful in future efforts to slow the progression of aMCI and aid in the development of novel therapeutics for age-related disorders of learning and memory. 

    References:

    . Environmental exposure to manganese in air: Associations with cognitive functions. Neurotoxicology. 2015 Jul;49:139-48. Epub 2015 Jun 19 PubMed.

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