. Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia. Mol Psychiatry. 2014 May 6; PubMed.

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  1. This is a pioneering and well-designed study. The preliminary results are promising, and undoubtedly will make a significant contribution to the growing body of research that aims to explore new applications for DBS in general, and DBS for AD in particular.

    However, it might have been more interesting if the authors had studied the changes in functional connectivity or any structural changes (before and after), as this could provide more objective data.

    Another important point that I would like to highlight is our need to spend more time and effort to find out the exact mechanism of DBS. The lack of knowledge regarding the precise mechanism of DBS can be considered one of the barriers for extending its clinical application. This is evident by the fact that the current paradigm for exploration of new applications of DBS is to experimentally screen different targets with different stimulation parameters.

    View all comments by Asem Salma

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  1. X Marks the Spot? Nucleus Basalis for DBS in Alzheimer’s