Sjögren M, Rosengren L, Minthon L, Davidsson P, Blennow K, Wallin A. Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD. Neurology. 2000 May 23;54(10):1960-4. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
NFL
(CSF)		 AD-
Early onset
(21)		 498 ± 236
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
NFL
(CSF)		 AD-
Late-onset
(21)		 1006 ± 727
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
NFL
(CSF)		 CTRL-
CNC
(18)		 241 ± 166
pg/mL		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 CTRL-
CNC
(18)		 241 ± 166
pg/mL		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 FTD
(18)		 1442 ± 1183
pg/mL		 ELISA;
Other/Not Specified;
In-house		 1994
albumin ratio
(CSF/Blood)		 AD-
Early onset
(21)		 6.4 ± 2.7
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 McKhann et al., 1984
albumin ratio
(CSF/Blood)		 AD-
Late-onset
(21)		 6.6 ± 1.8
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 McKhann et al., 1984
albumin ratio
(CSF/Blood)		 CTRL-
CNC
(18)		 5.3 ± 2
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)		 CTRL-
CNC
(18)		 5.3 ± 2
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
Other/Not Specified
albumin ratio
(CSF/Blood)		 FTD
(18)		 5.8 ± 1.9
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
Other/Not Specified		 1994
tau-total
(CSF)		 AD-
Early onset
(21)		 751 ± 394
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 AD-
Late-onset
(21)		 699 ± 319
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(18)		 375 ± 176
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 CTRL-
CNC
(18)		 375 ± 176
pg/mL		 ELISA;
Innotest;
Innogenetics
tau-total
(CSF)		 FTD
(18)		 354 ± 140
pg/mL		 ELISA;
Innotest;
Innogenetics		 1994

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AlzBiomarker

  1. AD vs CTRL : NFL (CSF)
  2. CTRL vs AD : NFL (CSF)
  3. FTD vs AD : NFL (CSF)
  4. AD vs CTRL : albumin ratio (CSF)
  5. CTRL vs AD : albumin ratio (CSF)
  6. FTD vs AD : albumin ratio (CSF)
  7. AD vs CTRL : tau-total (CSF)
  8. CTRL vs AD : tau-total (CSF)
  9. FTD vs AD : tau-total (CSF)

Mutations