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  1. It is not clear whether the authors used appropriate unbiased stereological methods to estimate numbers of neurons, NFT and plaques.

  2. One of the first papers showing clearly, with an excellent approach, what was expected: there is a relationship between the presence of tangles and neuronal loss. Also, cognitive impairment is better correlated with the density of tangles than with the neuronal loss.

  3. One of the first papers showing clearly, with an excellent approach, what was expected: there is a relationship between the presence of tangles and neuronal loss. Also, cognitive impairment is better correlated with the density of tangles than with the neuronal loss.

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