Rissman RA, Lee KF, Vale W, Sawchenko PE.
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation.
J Neurosci. 2007 Jun 13;27(24):6552-62.
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Stress exacerbates many, if not most, diseases. That stress appears to play a role in Alzheimer disease progression is not surprising; however, a molecular mechanism underlying this phenomenon has been lacking. In this paper, Rissman et al. demonstrate a pathway whereby an "emotional" stressor, such as restraint stress, can alter tau phosphorylation in mice. This effect is independent of glucocorticoids, but dependent on corticotropin releasing factor (CRF) receptors.
Our group recently published a very similar study, assessing the effect of several stressors, including restraint stress, on interstitial fluid (ISF) Aβ levels (Kang et al., 2007). We demonstrated that restraint stress acutely increased ISF Aβ levels, which was dependent on CRF but independent of glucocorticoids. Using very different approaches, our group and Rissman and colleagues may have identified the same pathway, one which could contribute to the two major Alzheimer disease pathologies. In the future, hopefully we will determine if the mechanisms from both of these studies do indeed overlap, and if so, how they are linked. And, of course most importantly, if this pathway does contribute to AD progression, we would like to determine if we can modulate the pathway to alleviate disease.
Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM.
Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity.
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10673-8.