. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014 May 30;344(6187):1023-8. PubMed.

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  1. Clearly, this is an amazing paper. The detail of the number and spatial location of proteins is remarkable. I appreciate their discussion of what the copy number of proteins may mean functionally; to compensate for a relatively small amount of endocytic machinery, the presynaptic terminal contains a vast excess of prepared synaptic vesicles.

    Applying this approach to all kinds of systems now, including AD, should yield incredible information. My bias will be to see how much APP is present and where it is located within the terminal.