. Chronically mad as a hatter: Anticholinergics and Alzheimer's disease pathology. Ann Neurol. 2003 Aug;54(2):144-146. PubMed.


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  1. An important paper. It would be good to have an exhaustive list of anticholinergics listed in order of their atropine equivalent effect.

    View all comments by Paul Chabun
  2. This is an important finding that adds to the human evidence pointing to a cholinergic-amyloid connection. Our group has contributed by showing that both muscarinic agonists and acetylcholinesterase inhibitors lower CSF and cortical ABeta levels in normal animals and both classes of drug also prevent the ABeta deposition induced experimentally by nucleus basalis lesion. It appears likely that the cortical cholinergic deficit associated with normal aging may be at least partially responsible for age-associated Abeta deposition and that cholinergic agents may be effective at preventing this. It is time for primary prevention trials of cholinergic agents for AD.

    View all comments by Thomas Beach

This paper appears in the following:


  1. Cholinergic Systems and AD: Dark Clouds and Silver Linings